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SRP6426

Sigma-Aldrich

E-Cadherin/ECAD/Cadherin-1/CD324 Protein human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

Sinonimo/i:

Arc-1, CDH1, LCAM, UVO

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in HEK 293 cells

Tag

6-His tagged (C-terminus)

Sterilità

sterile

Saggio

≥90% (SDS-PAGE)

Forma fisica

lyophilized

PM

calculated mol wt 67 kDa
observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)

Confezionamento

pkg of 25 μg

N° accesso UniProt

P12830

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... CDH1(999)

Descrizione generale

Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1.

Azioni biochim/fisiol

Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer.

Stato fisico

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping.
Huntsman DG and Caldas C
Cytogenetics and Cell Genetics, 83, 82-82 (1998)
Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
Ishiguro H, et al.
World Journal of Surgical Oncology, 14, 240-240 (2016)
miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/?-Catenin and Notch-1/Akt Signaling Pathways.
Song H, et al.
International Journal of Molecular Sciences, 17, E1799-E1799 (2016)
Variants of the CDH1 (E-Cadherin) Gene Associated with Oral Clefts in the Thai Population.
Ittiwut R, et al.
Genetic Testing and Molecular Biomarkers, 20, 406-406 (2016)
Dapeng Sun et al.
PloS one, 17(9), e0274919-e0274919 (2022-09-23)
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR

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