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Merck
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Documenti fondamentali

SRP6371

Sigma-Aldrich

Aldose Reductase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinonimo/i:

ADR, AKR1B1, ALDR1, ALR2, AR, Aldo-keto reductase family1, member B1

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About This Item

Codice UNSPSC:
12352204
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥95% (SDS-PAGE)

Stato

liquid

PM

35.8 kDa (316 aa, 1-316 aa)

Confezionamento

pkg of 100 μg

Concentrazione

1 mg/mL

N° accesso UniProt

P15121

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... AKR1B1(231)

Descrizione generale

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily. Recombinant aldose reductase (AKR1B) protein was expressed in Escherichia coli and purified by using conventional chromatography techniques. It is expressed in eye and kidney, but predominant in placenta. The AKR1B1 gene is mapped to human chromosome 7q33.

Azioni biochim/fisiol

Aldose reductase (AKR1B1) catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 is also involved in cytokine-mediated generation of prostaglandin F2α (PGF2α) in preadipocytes. It participates in diabetes-associated mitochondrial disorder and damage via the activation of p53. AKR1B1 is associated with drug resistance mechanism in cancer-derived cell lines. It is also known to mediate cellular processes linked to carcinogenesis such as EMT (epithelial–mesenchymal transition), inflammation and angiogenesis. Aldose reductase mediates glucose metabolism in placenta and osmotic control in eye and kidney.

Stato fisico

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
8E06L73610
7F16L73610
7M22L73610
6A10L73610
7C03L73610

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The crystal structure of the aldose reductase.NADPH binary complex.
Borhani DW, et al.
The Journal of Biological Chemistry, 267, 24841-24847 (1992)
Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers.
Laffin B and Petrash JM
Frontiers in Pharmacology, 3, 104-104 (2012)
Candidate locus analysis for PHACE syndrome.
Mitchell S, et al.
American Journal of Medical Genetics. Part A, 158(6), 1363-1367 (2012)
The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium.
Bresson E, et al.
The Journal of Clinical Endocrinology and Metabolism, 96, 210-219 (2011)
Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: modulation by inflammatory cytokines and role of the human aldose reductase AKR1B1.
Michaud A, et al.
PLoS ONE, 9, e90861-e90861 (2014)
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