SRP0400
PRMT4 peptide, biotin
≥90% (HPLC)
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Saggio
≥90% (HPLC)
Forma fisica
aqueous solution
Confezionamento
pkg of 80 nmol
Concentrazione
400 μM
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... CARM1(10498)
Descrizione generale
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
Applicazioni
Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.
Azioni biochim/fisiol
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
Stato fisico
Supplied in a TRIS-buffered solution.
Altre note
200 μL at 400 μM, or 80 nmol. Sold as 80 nmol
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
High-resolution genomic profiling of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) patients identified novel recurrent copy number variations involved in both pathogenesis and resistance to tyrosine kinase inhibitors
Ilaria Lacobucci
Cancer Research, 68(9) (2008)
PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
Gundula Streubel
PLoS Genetics, 9(3), e1003343-e1003343 (2013)
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Jacques SL
Biochemistry, 55(11), 1635-1644 (2016)
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