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This product is not tested for in vivo or in vitro use. Several publication indicate that this compound has been used successfully in mouse models. Please see the links below to review publications that may be of interest.
https://pubmed.ncbi.nlm.nih.gov/36873175/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669869/
SML3078
JT003 trifluoroacetate
≥95% (HPLC)
Sinonimo/i:
P-Nva-LYYFA trifluoroacetate
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Cambia visualizzazione
5 MG
CHF 129.00
About This Item
Formula empirica (notazione di Hill):
C46H62N8O9 · xC2HF3O2
Peso molecolare:
871.03 (free base basis)
Codice UNSPSC:
51111800
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥95% (HPLC)
Stato
film or powder
Colore
white to off-white
Temperatura di conservazione
−20°C
Azioni biochim/fisiol
JT003 is potent dual agonist of adiponectin receptors AdipoR1/AdipoR2 that potently improves insulin resistance in high fat diet induced nonalcoholic steatohepatitis (NASH) mice. JT003 inhibits hepatic stellate cells (HSCs) activation in CCl4 induced liver fibrosis.
potent dual agonist of adiponectin receptors AdipoR1/AdipoR2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Michishige Terasaki et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are
Hongjiao Xu et al.
Nature communications, 11(1), 5807-5807 (2020-11-18)
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs
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Good afternoon, I would like to know the solubility of compound JT003 for in vivo experiments on mice. Thank you. Maria
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