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R9156

Sigma-Aldrich

Raltitrexed

≥98% (HPLC), solid

Sinonimo/i:

L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl), ICI-D-1694, ZD-1694

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10 MG
CHF 202.00
50 MG
CHF 600.00

About This Item

Formula empirica (notazione di Hill):
C21H22N4O6S
Numero CAS:
112887-68-0
Peso molecolare:
458.49
Codice UNSPSC:
12352200
ID PubChem:
329824044
NACRES:
NA.77

CHF 202.00

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Saggio

≥98% (HPLC)

Stato

solid

Colore

off-white to light yellow

Solubilità

H2O: ≥10 mg/mL
DMSO: ≥40 mg/mL

Ideatore

AstraZeneca

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

Azioni biochim/fisiol

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives.
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H300,H360

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 2 Oral - Repr. 1B

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
081M4721V
128K47102
128K47101
128K4710

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Pemetrexed disodium heptahydrate ≥98% (HPLC)

Sigma-Aldrich

SML1490

Pemetrexed disodium heptahydrate

USP

USP

1500659

Pemetrexed disodium

Helena Almqvist et al.
Nature communications, 7, 11040-11040 (2016-03-25)
Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on
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