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Documenti fondamentali

R4632

Sigma-Aldrich

Retinil acetato

synthetic, crystalline solid or supercooled liquid

Sinonimo/i:

Retinolo acetato, Vitamina A acetato

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About This Item

Formula empirica (notazione di Hill):
C22H32O2
Numero CAS:
Peso molecolare:
328.49
Beilstein:
1915439
Numero CE:
Numero MDL:
Codice UNSPSC:
12352205
eCl@ss:
34058009
ID PubChem:
NACRES:
NA.79
Prezzi e disponibilità al momento non sono disponibili

Origine biologica

synthetic

Saggio

≥90% (HPLC)

Stato

crystalline solid or supercooled liquid

Potenza

2,600,000-2,940,000 I.U. per g

Colore

light yellow to dark yellow

Punto di fusione

57-58 °C
~58 °C (lit.)

Temperatura di conservazione

−20°C

Stringa SMILE

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
QGNJRVVDBSJHIZ-QHLGVNSISA-N

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Descrizione generale

Vitamin A usually occurs in food as retinyl esters,[1] which are the pre-formed sources of vitamin A.[2] Retinyl acetate exists as yellow crystals and is insoluble in water. It is soluble in ethanol and oils.[3]

Applicazioni

Retinyl acetate has been used:
  • to study its effects on cochlear development in mice[4]
  • as a component of an internal standard to quantify antioxidants in yolk[4]
  • as an internal standard to determine serum retinol concentration[5]

Azioni biochim/fisiol

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.

Stato fisico

Packaged as a melt and may exist as a crystalline solid or a supercooled viscous liquid

Risultati analitici

Activity based on HPLC comparison to USP standard.

Pittogrammi

Health hazard

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Aquatic Chronic 4 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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Certificati d'analisi (COA)

Lot/Batch Number

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The common marmoset in captivity and biomedical research
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Encyclopedia of Separation Science (2007)
Assessment of the relative dose-response test based on serum retinol-binding protein instead of serum retinol in determining low hepatic vitamin A stores
Fujita M, et al.
American Journal of Clinical Nutrition (2009)
Effects of retinoid treatment on cochlear development, connexin expression and hearing thresholds in mice
Kim Yy, et al.
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale (2018)
Buhler Volker
Vademecum for Vitamin Formulations (2001)

Protocolli

GB method with Ascentis® Express C30 column achieves baseline resolution for Vitamin A and E critical pair.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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