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P8813

Sigma-Aldrich

Protriptyline hydrochloride

≥99% (TLC), powder

Sinonimo/i:

N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C19H21N · HCl
Numero CAS:
1225-55-4
Peso molecolare:
299.84
Numero CE:
214-956-3
Numero MDL:
MFCD00072057
Codice UNSPSC:
12352200
ID PubChem:
24277801
NACRES:
NA.77

Saggio

≥99% (TLC)

Stato

powder

Colore

white to off-white

Solubilità

H2O: 50 mg/mL

Stringa SMILE

Cl[H].CNCCCC1c2ccccc2C=Cc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
OGQDIIKRQRZXJH-UHFFFAOYSA-N

Informazioni sul gene

human ... SLC6A2(6530) , SLC6A4(6532)

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Azioni biochim/fisiol

Norepinephrine uptake blocker.

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Shelf-life of the powder is at least three years at room temperature.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H312 + H332,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
SLBG1302V
SLBC3353V
057K1493
082K0596
025H0506

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M M Makhay et al.
Pharmacology, biochemistry, and behavior, 63(2), 319-324 (1999-06-17)
The ability of indirectly acting agonists such as norepinephrine uptake inhibitors, serotonin reuptake inhibitors, and atypical antidepressants to substitute for clenbuterol, a beta-2 adrenergic agonist, was examined in rats trained to discriminate 0.03 mg/kg clenbuterol and saline using a fixed-ratio
B Wroblewski et al.
Brain injury, 7(4), 353-362 (1993-07-01)
The results of a series of eight individual case reports in which protriptyline, an activating tricyclic antidepressant, was used as a 'stimulant' medication are presented. For some patients with head injury, traditional stimulants, such as methylphenidate, or dopaminergic stimulants, such
K E Kinnamon et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 216(3), 424-428 (1997-12-24)
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective
Malcolm Kohler et al.
Expert opinion on investigational drugs, 18(5), 647-656 (2009-04-25)
Currently the treatment of choice for symptomatic obstructive sleep apnoea (OSA) is continuous positive airway pressure (CPAP). Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would
Nonsurgical management of the obstructive sleep apnea patient.
W K Thornton et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 54(9), 1103-1108 (1996-09-01)
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