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Key Documents

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P3766

Sigma-Aldrich

Phorbol 12-myristate 13-acetate 4-O-methyl ether

Sinonimo/i:

MPMA

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About This Item

Formula empirica (notazione di Hill):
C37H58O8
Numero CAS:
57716-89-9
Peso molecolare:
630.85
Beilstein:
6554604
Numero MDL:
MFCD00036790
Codice UNSPSC:
12352211
ID PubChem:
24898450
NACRES:
NA.25

Temperatura di conservazione

−20°C

Livello qualitativo

100

Stringa SMILE

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(OC)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C37H58O8/c1-8-9-10-11-12-13-14-15-16-17-18-19-30(40)44-33-25(3)36(42)28(31-34(5,6)37(31,33)45-26(4)39)21-27(23-38)22-35(43-7)29(36)20-24(2)32(35)41/h20-21,25,28-29,31,33,38,42H,8-19,22-23H2,1-7H3/t25-,28+,29-,31-,33-,35-,36-,37-/m1/s1
VCWNAJUHTLWQQT-XCHBPHIQSA-N

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Azioni biochim/fisiol

Weak phorbol ester agonist; very weak inflammatory and tumor promoting agent.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H315,H319

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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H Ling et al.
British journal of pharmacology, 161(8), 1763-1777 (2010-08-20)
Shogaols are reported to possess anti-inflammatory and anticancer activities. However, the antimetastatic potential of shogaols remains unexplored. This study was performed to assess the effects of shogaols against breast cancer cell invasion and to investigate the underlying mechanisms. The anti-invasive
Jason A Bartos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(2), 449-463 (2010-01-15)
The tyrosine kinase Pyk2 plays a unique role in intracellular signal transduction by linking Ca(2+) influx to tyrosine phosphorylation, but the molecular mechanism of Pyk2 activation is unknown. We report that Pyk2 oligomerization by antibodies in vitro or overexpression of
Anke Sichelstiel et al.
PloS one, 9(2), e98440-e98440 (2014-06-12)
For patients with chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), exacerbations are life-threatening events causing acute respiratory distress that can even lead to hospitalization and death. Although a great deal of effort has been put into research
Simon Ittig et al.
PLoS pathogens, 8(5), e1002667-e1002667 (2012-05-10)
Capnocytophaga canimorsus is a usual member of dog's mouths flora that causes rare but dramatic human infections after dog bites. We determined the structure of C. canimorsus lipid A. The main features are that it is penta-acylated and composed of
Soroush Sharbati et al.
Microorganisms, 7(3) (2019-03-02)
Pathogenic mycobacteria are able to persist intracellularly in macrophages, whereas non-pathogenic mycobacteria are effectively combated and eliminated after their phagocytosis. It is known that TGF-β plays an important role in this context. Infection with pathogenic mycobacteria such as Mycobacterium tuberculosis
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