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P0472

Sigma-Aldrich

Pilocarpine hydrochloride

meets USP testing specifications

Sinonimo/i:

(3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C11H16N2O2 · HCl
Numero CAS:
54-71-7
Peso molecolare:
244.72
Beilstein:
4034491
Numero CE:
200-212-5
Numero MDL:
MFCD00012722
Codice UNSPSC:
12352200
ID PubChem:
24898106
NACRES:
NA.21

agenzia

USP/NF
meets USP testing specifications

Stato

solid

Punto di fusione

202-205 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
RNAICSBVACLLGM-GNAZCLTHSA-N

Informazioni sul gene

human ... CHRM1(1128) , CHRM3(1131)

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Azioni biochim/fisiol

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number
SLCD0069
SLBT0365
SLBM0384V
SLBD4477V
079K1144

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Maxime Lévesque et al.
Seizure, 25, 18-25 (2015-02-04)
Mesial temporal lobe epilepsy (MTLE) is the most prevalent type of partial epileptic disorders. In this study, we have analyzed the impact of levetiracetam (LEV) in the pilocarpine model of MTLE. Sprague-Dawley rats (n=19) were injected with pilocarpine (380 mg/kg
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Kevin D Phelan et al.
Molecular pharmacology, 83(2), 429-438 (2012-11-29)
Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated
Mi-Hyeon Jang et al.
Cell stem cell, 12(2), 215-223 (2013-02-12)
Adult neurogenesis, the process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying the activity-dependent regulation of the sequential steps
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