N7537

NSC 663284

≥98% (HPLC), solid

• Sinonimo/i: 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Formula empirica (notazione di Hill): C₁₅H₁₆ClN₃O₃
• Numero CAS: 383907-43-5
• Peso molecolare: 321.76
• Numero MDL: MFCD08276924
• Codice UNSPSC: 12352200
• ID PubChem: 24724556
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Condizioni di stoccaggio: protect from light
• Colore: red
• Solubilità: DMSO: ≥10 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2; BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Informazioni sul gene: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Descrizione

Applicazioni

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Azioni biochim/fisiol

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 470.1 °F
• Punto d’infiammabilità (°C): 243.4 °C
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves