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N3385

Sigma-Aldrich

N-Nitroso-N-ethylurea

ISOPAC®

Sinonimo/i:

ENU, N-Ethyl-N-nitrosourea

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About This Item

Formula empirica (notazione di Hill):
C3H7N3O2
Numero CAS:
759-73-9
Peso molecolare:
117.11
Numero CE:
212-072-2
Numero MDL:
MFCD00053635
Codice UNSPSC:
12352102
ID PubChem:
24897640
NACRES:
NA.25

Forma fisica

powder

Temperatura di conservazione

−20°C

Stringa SMILE

CCN(N=O)C(N)=O

InChI

1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
FUSGACRLAFQQRL-UHFFFAOYSA-N

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Applicazioni

N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.

Azioni biochim/fisiol

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Confezionamento

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
1 vial contains 1 g of material calculated on anhydrous basis.

Avvertenza

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Ricostituzione

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Note legali

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H312 + H332,H350,H360

Classi di pericolo

Acute Tox. 3 Oral - Carc. 1B - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Induction of mutations by ENU in the medaka germline.
Ishikawa Y
The fish biology journal Medaka, 10, 27-29 (1999)
Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant.
Biehlmaier O, et al.
Investigative Ophthalmology & Visual Science, 44, 1287-1287 (2003)
Mouse mutagenesis using N-ethyl-N-nitrosourea (ENU).
Salinger AP and Justice MJ
Cold Spring Harbor Protocols, 4 (2008)
Georgina Caruana et al.
PloS one, 8(3), e55429-e55429 (2013-03-08)
Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in organogenesis we conducted a phenotype-driven, genome-wide
Jinjun Dang et al.
Blood, 125(23), 3609-3617 (2015-04-10)
Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most commonly involve PAX5, encoding the DNA-binding transcription factor paired-box 5. The majority of PAX5 alterations in ALL are heterozygous, and
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