N5501

N_ω-Nitro-L-arginine

≥98% (TLC)

• Sinonimo/i: L-NNA, N⁵-(Nitroamidino)-L-2,5-diaminopentanoic acid, N^G-NO₂-L-Arg
• Formula empirica (notazione di Hill): C₆H₁₃N₅O₄
• Numero CAS: 2149-70-4
• Peso molecolare: 219.20
• Beilstein: 1728914
• Numero CE: 218-418-9
• Numero MDL: MFCD00007033
• Codice UNSPSC: 12352209
• ID PubChem: 24278010
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Punto di fusione: 257 °C
• Solubilità: 1 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• Stringa SMILE: N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
• InChI: 1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1; MRAUNPAHJZDYCK-BYPYZUCNSA-N
• Informazioni sul gene: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Grin2a(24409) , Nos1(24598)

Descrizione

Applicazioni

N_ω-Nitro-L-arginine has been used:

• as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay
• to pretreat fiber bundles for contractile studies
• as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells
• as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations

Azioni biochim/fisiol

N_ω-Nitro-L-arginine/L-NNA helps to reduce the levels of cortical hyperemia and brain cGMP occurring due to hypercapnia.

Irreversible inhibitor of constitutive nitric oxide synthase (nNOS) and a reversible inhibitor of inducible nitric oxide synthase (iNOS).

Caratteristiche e vantaggi

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)