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N4038

Sigma-Aldrich

Anticorpo anti-NAV3 (regione N-terminale)

enhanced validation

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~280 kDa

Reattività contro le specie

rat (predicted), human, mouse (predicted)

Confezionamento

antibody small pack of 25 μL

Convalida avanzata

recombinant expression
Learn more about Antibody Enhanced Validation

Concentrazione

~1 mg/mL

tecniche

western blot: 1-2 μg/mL using HEK-293T cells lysate expressing human NAV3 fusion protein

N° accesso UniProt

Q8IVL0

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NAV3(89795)
mouse ... Nav3(260315)
rat ... Nav3(314814)

Categorie correlate

Descrizione generale

NAV3 (neuron navigator 3, also known as unc-53H3, steerin3, POMFIL1) belongs to the neuron navigator (NAV) family of proteins. NAV proteins are predominantly expressed in the nervous system. NAV3 expression is detected in brain.
NAV3 is made up of a calponin homology (CH) domain, a cytoskeletal interacting domain (CSID), four coiled-coil (CC) domains, and an AAA-domain.
Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.

Specificità

Anti-NAV3 (N-terminal) specifically recognizes human NAV3.

Azioni biochim/fisiol

NAV3 (neuron navigator 3) has been suggested to function as a novel tumor suppressor gene. It is a putative haploin sufficient tumor suppressor gene, which helps in the growth, differentiation and apoptosis of cutaneous T-cell lymphoma (CTCL)cells.
NAV3 gene deletions and translocation affect patients with advanced mycosis fungoides or Sezary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL), suggesting that it may provide a novel diagnostic tool.
Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stoccaggio e stabilità

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Apoorva Uboveja et al.
Oncogenesis, 9(2), 12-12 (2020-02-08)
p73 is a member of the p53 tumor suppressor family, which transactivates p53-responsive genes and mediates DNA damage response. Recent evidences suggest that p73 exerts its tumor suppressor functions by suppressing metastasis, but the exact mechanism remains unknown. Here, we
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue
Karenko Leena, et al.
Cancer Research, 65(18), 8101-8110 (2005)
Hadas Cohen-Dvashi et al.
EMBO molecular medicine, 7(3), 299-314 (2015-02-14)
Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator-3 (NAV3), a gene frequently mutated or deleted in human tumors, as a regulator of epithelial migration and invasion. Following induction by growth factors, NAV3 localizes
Pilvi Maliniemi et al.
Experimental dermatology, 20(11), 926-931 (2011-10-15)
The neuron navigator 3 (NAV3) gene on chromosome 12q21 encodes a microtubule plus end tracking protein and belongs to the navigator family of cytoskeletal regulators. Loss of heterozygosity on 12q has previously been suggested to be associated with poor prognosis
E Carlsson et al.
British journal of cancer, 106(3), 517-524 (2011-12-17)
The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). We analysed changes in chromosome 12 and NAV3 copy number in
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