Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

N0290

Sigma-Aldrich

Nitazoxanide

≥98% (HPLC)

Sinonimo/i:

NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C12H9N3O5S
Numero CAS:
55981-09-4
Peso molecolare:
307.28
Numero CE:
259-931-8
Numero MDL:
MFCD00416599
Codice UNSPSC:
12352200
ID PubChem:
329818424
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Ideatore

Romark

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O

InChI

1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
YQNQNVDNTFHQSW-UHFFFAOYSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Nitazoxanide (NTZ), a thiazolide compound is a antiparasitic drug with structure similar to niclosamide.

Applicazioni

Nitazoxanide has been used:
  • to test its anti-viral activity against chikungunya virus
  • as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines
  • to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells

Azioni biochim/fisiol

Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria. It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies. NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV). It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Caratteristiche e vantaggi

This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 9

1 of 9

Ritonavir ≥98% (HPLC)

Sigma-Aldrich

SML0491

Ritonavir

Darunavir ≥98% (HPLC)

Sigma-Aldrich

SML0937

Darunavir

2-Amino-5-nitrothiazole 97%

Sigma-Aldrich

133507

2-Amino-5-nitrothiazole

2,4-Dinitrophenol moistened with water, ≥98.0%

Sigma-Aldrich

D198501

2,4-Dinitrophenol

Chloroquine diphosphate salt powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Chloroquine diphosphate salt

Lopinavir ≥98% (HPLC)

Sigma-Aldrich

SML1222

Lopinavir

Hydroxychloroquine sulfate ≥98% (HPLC), powder

Sigma-Aldrich

H0915

Hydroxychloroquine sulfate

Oxaliplatin powder

Sigma-Aldrich

O9512

Oxaliplatin

Potassium dichromate ACS reagent, ≥99.0%

Sigma-Aldrich

207802

Potassium dichromate

Vanessa R Anderson et al.
Drugs, 67(13), 1947-1967 (2007-08-29)
Nitazoxanide (Alinia, Daxon, Dexidex, Paramix, Kidonax, Colufase, Annita) has in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is effective in the treatment of protozoal and helminthic infections, including Cryptosporidium parvum or
P Patrick Basu et al.
The American journal of gastroenterology, 106(11), 1970-1975 (2011-10-13)
Resistance to standard Helicobacter pylori (HP) treatment regimens has led to unsatisfactory cure rates in HP-infected patients. This study was designed to evaluate a novel four-drug regimen (three antibiotics and a proton pump inhibitor (PPI)) for eradication of HP infection
Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis
Lam KYK
PLoS Pathogens, 8(5), 340-351 (2012)
Irit Krause et al.
The Pediatric infectious disease journal, 31(11), 1135-1138 (2012-07-20)
Cryptosporidium parvum is a common cause of diarrhea. In immunocompetent individuals, spontaneous recovery is the rule. In immunocompromised patients, it may cause a serious disease. Data on cryptosporidiosis in children after solid organ transplantation are few. We report on 6
G Esmat et al.
Liver international : official journal of the International Association for the Study of the Liver, 32 Suppl 1, 146-150 (2012-01-11)
Hepatitis C virus genotype 4 (HCV-4) is the most common type of hepatitis C virus (HCV) in the Middle East and Africa, in particular Egypt. Since the development of new protease inhibitors, the response of HCV-4 to the standard regimen
Visualizza tutti i documenti correlati

Articoli

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.