M2537

Mevastatin

≥98% (HPLC), powder or crystals

• Sinonimo/i: Compactin, ML-236B
• Formula empirica (notazione di Hill): C₂₃H₃₄O₅
• Numero CAS: 73573-88-3
• Peso molecolare: 390.51
• Beilstein: 1269441
• Numero MDL: MFCD05662341
• Codice UNSPSC: 12352200
• ID PubChem: 24278540
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder or crystals
• Colore: white to light yellow
• Punto di fusione: 151 °C
• Solubilità: ethanol: 25-26 mg/mL, clear, colorless
• Spettro attività antibiotica: neoplastics
• Modalità d’azione: enzyme | inhibits
• Ideatore: Daiichi-Sankyo
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1; AJLFOPYRIVGYMJ-INTXDZFKSA-N
• Informazioni sul gene: human ... HMGCL(3155) , HMGCR(3156) ; rat ... Hmgcr(25675)

Descrizione

Descrizione generale

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.

Applicazioni

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro

Azioni biochim/fisiol

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi. It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras. Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.

Caratteristiche e vantaggi

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)