M0567
Microsomes from Liver, Pooled
from human male
Sinonimo/i:
lab equipment accessory
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1 VIAL
CHF 475.00
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1 VIAL
CHF 475.00
About This Item
Codice UNSPSC:
12352204
NACRES:
NA.54
Prodotti consigliati
Origine biologica
human male
Livello qualitativo
Stato
liquid
Confezionamento
vial of ~10 mg
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
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Applicazioni
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process[1]
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)[2]
- to study the metabolization of enantiomeric peptide D3[3]
Azioni biochim/fisiol
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes. [6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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