M9441
Microsomes from Liver, Pooled
from mouse(CD-1), male
Sinonimo/i:
lab equipment accessory
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Cambia visualizzazione
1 VIAL
CHF 173.00
About This Item
Codice UNSPSC:
12161501
NACRES:
NA.47
Origine biologica
mouse (CD-1)
Livello qualitativo
Stato
liquid
Confezionamento
vial of ~10 mg
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
mouse ... Mgst1(56615)
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Descrizione generale
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]
Applicazioni
Microsomes from Liver, Pooled has been also been used to study the metabolic stability of antitumor agents[2] and tunicamycin.[3]
Microsomes from Liver, Pooled has been used in cell survival and mutation assays in Escherichia coli.[4]
Azioni biochim/fisiol
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[5] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.[6]
Source of drug metabolizing enzymes, including cytochrome P-450.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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