H4791
BMP2, human
BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture
Sinonimo/i:
Bone Morphogenetic Protein 2 human, BMP-2
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10 μG
CHF 350.00
CHF 350.00
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Cambia visualizzazione
10 μG
CHF 350.00
About This Item
CHF 350.00
Check Cart for Availability
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Nome del prodotto
Bone Morphogenetic Protein 2 human, BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in HEK 293 cells
Stato
lyophilized powder
Potenza
≤60 ng/mL EC50
Qualità
endotoxin tested
PM
dimer 30-38 kDa (glycosylated)
Confezionamento
pkg of 10 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
≤1 EU/μg Endotoxin level
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... BMP2(650)
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Descrizione generale
Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.
Azioni biochim/fisiol
It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.
Stato fisico
Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.
Nota sulla preparazione
This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.
Risultati analitici
The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).
Note legali
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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