This product does not have a color specification for the solution upon solubilizing. It is soluble in water (50 mg/ml) and in DMSO (10 mg/ml), yielding a clear solution. Mild warming may be required to fully dissolve the material. If the solution is clear and slightly yellowish, it should be acceptable for use.
The recommended storage temperature for this product is 2–8 °C. If unopened and stored at 4–8 °C, it is guaranteed for 1 year from the date of shipment. Additional information is available in the product datasheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdf
D5207
Doxiciclina
powder, suitable for cell culture, BioReagent
Sinonimo/i:
Doxycycline hydrochloride hemiethanolate hemihydrate
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About This Item
Formula empirica (notazione di Hill):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
Numero CAS:
Peso molecolare:
512.94
Beilstein:
5702728
Numero MDL:
Codice UNSPSC:
12352207
NACRES:
NA.22
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Nome del prodotto
Doxiciclina, Suitable for Cell Culture
Livello qualitativo
Stato
powder
Temperatura di conservazione
2-8°C
Stringa SMILE
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
InChI
1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1
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Categorie correlate
Descrizione generale
General description
Chemical structure: tetracycline
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Chemical structure: tetracycline
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.
Applicazioni
Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Azioni biochim/fisiol
Modalità d′azione: La doxiciclina iclato inibisce la risposta infiammatoria alla Spirochete Borrelia burgdorferi responsabile della malattia di Lyme.
Spettro di azione: Efficace nei confronti di inibitori ad ampio spettro delle metalloproteinasi della matrice in vivo.
Spettro di azione: Efficace nei confronti di inibitori ad ampio spettro delle metalloproteinasi della matrice in vivo.
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Confezionamento
1, 5, 10 g in glass bottle
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Certificati d'analisi (COA)
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Question related to Stephane F's and the answer. I resuspended in DMSO but the solution that I have is slightly yellow is that okay? Also how long does the powder last at 4C?
1 answer-
Helpful?
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What temperature should a solution be stored?
1 answer-
As stated in the 'PROPERTIES' section, the recommended storage temperature for this product is 2–8 °C. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdfHelpful?
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Is this product suitable for in-vivo use (added to drinking water)? Also what is the difference between this product (D5207) and D9891? thank you
1 answer-
This product is intended for research use only. It is not suitable for human or veterinary use. The material has not been tested in animal models for ingestion. The end user would need to determine suitability. The major difference between product D5207 and D9891 is the testing performed. Product D5207 is tested suitable for cell culture applications. Please see the product specification sheet below regarding testing:
https://www.sigmaaldrich.com/specification-sheets/330/944/D5207-10G.pdf
https://www.sigmaaldrich.com/specification-sheets/323/301/D9891-25G.pdfHelpful?
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Hello. I have a question regarding the ref D5207 Doxycycline hyclate. I would like to know how I can resuspend the powder (DMSO, H2O, etc...). And at which concentration. Is that 10 mg/ml ok ? Thank you.
1 answer-
This product is soluble in water (50 mg/mL), and in DMSO (10 mg/mL) yielding a clear solution. Mild warming may be required to fully dissolve the material.
Please see the product data sheet for more information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/297/d5207dat.pdfHelpful?
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