D1756

Desametasone

≥98% (HPLC), powder, NOS induction inhibitor

• Sinonimo/i: (11β,16α)-9-fluoro-11,17,21-triidrossi-16-metilpregna-1,4-diene-3,20-dione, 9α-fluoro-16α-metil-11β,17α,21-triidrossi-1,4-pregnadiene-3,20-dione, 9α-fluoro-16α-metilprednisolone, Prednisolone F
• Formula empirica (notazione di Hill): C₂₂H₂₉FO₅
• Numero CAS: 50-02-2
• Peso molecolare: 392.46
• NACRES: NA.77
• PubChem Substance ID: 24893536
• UNSPSC Code: 51422306
• EC Number: 200-003-9
• MDL number: MFCD00064136
• Beilstein/REAXYS Number: 2066651
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Desametasone, ≥98% (HPLC), powder
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: off-white
• mp: 262-264 °C (lit.)
• solubility: methanol: 25 mg/mL
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908) ; mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926) ; rat ... Ar(24208), Nr3c1(24413), Tnf(24835) ;

Descrizione

General description

Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways, some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.

Application

Dexamethasone has been used:

• in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue
• as a component of adipocyte differentiation medium
• for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)

Biochem/physiol Actions

Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.

Agente antinfiammatorio glucocorticoide

Agente antinfiammatorio glucocorticoide. Regola la sopravvivenza, la crescita e la differenziazione delle cellule T. Inibisce l′induzione dell′ossido nitrico sintasi.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.

Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Parola di avvertenza: Danger
• Codici di pericolo: H360FD
• Avvertenze di sicurezza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): dust mask type N95 (US), Eyeshields, Faceshields, Gloves