C7744

Combretastatin A4

≥98% (HPLC), powder

• Sinonimo/i: 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene, 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, CA4
• Formula empirica (notazione di Hill): C₁₈H₂₀O₅
• Numero CAS: 117048-59-6
• Peso molecolare: 316.35
• Numero MDL: MFCD03453309
• Codice UNSPSC: 12352200
• ID PubChem: 329775149
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: off-white
• Solubilità: DMSO: >10 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
• InChI: 1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-; HVXBOLULGPECHP-WAYWQWQTSA-N

Descrizione

Descrizione generale

Combretastatin A4 belong to the class of colchicinoids compounds.[1]

Applicazioni

Combretastatin A4 has been used:

• as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase[2]
• to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models[1]
• as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae[3]

Azioni biochim/fisiol

Combretastatin A4 is a potent microtubule targeting agent (MTA).[1]

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311 + H331,H318
• Consigli di prudenza: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges