C6643

Clofibrate

liquid

• Sinonimo/i: 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate
• Formula empirica (notazione di Hill): C₁₂H₁₅ClO₃
• Numero CAS: 637-07-0
• Peso molecolare: 242.70
• Beilstein: 1913459
• Numero CE: 211-277-4
• Numero MDL: MFCD00000615
• Codice UNSPSC: 12352200
• ID PubChem: 24278085
• NACRES: NA.77

Proprietà

• Stato: liquid
• Colore: clear colorless
• Densità: 1.14 g/mL at 25 °C (lit.)
• Ideatore: Wyeth
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
• InChI: 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3; KNHUKKLJHYUCFP-UHFFFAOYSA-N
• Informazioni sul gene: human ... PPARA(5465) ; mouse ... Ppara(19013)

Descrizione

Applicazioni

Clofibrate has been used:

• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection[1]
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells[2]
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes[3]

Azioni biochim/fisiol

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist.[4] It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.[5]

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H318,H335
• Consigli di prudenza: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 235.4 °F - closed cup
• Punto d’infiammabilità (°C): 113 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter