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C5157

Sigma-Aldrich

Campesterol

~65%

Sinonimo/i:

24α-Methyl-5-cholesten-3β-ol, 24(R)-Ergost-5-en-3β-ol

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About This Item

Formula empirica (notazione di Hill):
C28H48O
Numero CAS:
Peso molecolare:
400.68
Beilstein:
3216975
Numero CE:
Numero MDL:
Codice UNSPSC:
12352211
ID PubChem:
NACRES:
NA.28

Origine biologica

Glycine max (soybean)

Forma fisica

powder

Concentrazione

~65%

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])[C@H](C)CC[C@H](C)C(C)C

InChI

1S/C28H48O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18-20,22-26,29H,7-8,10-17H2,1-6H3/t19-,20+,22-,23-,24+,25-,26-,27-,28+/m0/s1
SGNBVLSWZMBQTH-ZRUUVFCLSA-N

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Applicazioni

Campesterol was used as standard in GC and HPLC analysis of oil samples from plants.

Azioni biochim/fisiol

Campesterol is a phytosterol, primarily found in nuts, fruits, legumes and seeds. Though an analogue of cholesterol, it is poorly absorbed in humans and competitively inhibits the absorption of cholesterol. Campesterol decreases the transcription of genes involved in cholesterol metabolism in hepatocytes and enterocytes and has positive impact in treatment of cardiovascular disease.
Plant sterol. May lower absorption of dietary cholesterol.

Qualità

Appears ~98% by HPLC and GC, but has been shown by 13C-NMR to contain ~35% dihydrobrassicasterol (24β-methyl-5-cholesten-3β-ol; 24[S]-ergost-5-en-3β-ol).

Nota sulla preparazione

Campesterol yields clear, colorless to faint yellow solution in chloroform at 20 mg/ml.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

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campestanol Avanti Research™ - A Croda Brand 700122P, powder

Avanti

700122P

campestanol

Fucosterol ≥93%

Sigma-Aldrich

F5379

Fucosterol

Stigmasterol phyproof® Reference Substance

PHL82658

Stigmasterol

β-Sitosterol primary reference standard

02090580

β-Sitosterol

Cycloartenol ≥90% (GC)

Sigma-Aldrich

08172

Cycloartenol

Sigma-Aldrich

Sigma-Aldrich

S462330

STIGMASTANOL

Phytosterol enrichment of rice bran oil by a supercritical carbon dioxide fractionation technique
Dunford NT and King JW
Journal of Food Science, 65, 1395-1399 (2000)
Myung-Hee Lee et al.
Journal of ginseng research, 41(3), 428-433 (2017-07-14)
In this study, the fermentation of ginseng seeds was hypothesized to produce useful physiologically-active substances, similar to that observed for fermented ginseng root. Ginseng seed was fermented using The ginseng seed was fermented inoculating 1% of each strain on sterilized
D Lütjohann et al.
Journal of lipid research, 36(8), 1763-1773 (1995-08-01)
Absorption of dietary cholesterol, campesterol, and sitosterol, cholesterol balance, and fecal excretion of plant sterols were determined in three unrelated patients with phytosterolemia and three healthy volunteers during constant intake of cholesterol and plant sterols using accurate gas-liquid chromatography-mass spectrometry
Hannu Päivä et al.
Clinical pharmacology and therapeutics, 78(1), 60-68 (2005-07-09)
Myopathy, probably caused by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in skeletal muscle, rarely occurs in patients taking statins. This study was designed to assess the effect of high-dose statin treatment on cholesterol and ubiquinone metabolism and mitochondrial function in human skeletal
S H Kasmas et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 45(11), 1095-1101 (2012-07-18)
Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial. Our study compared the effects of two equally effective lipid-lowering strategies

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