C3144

Coenzyme A sodium salt hydrate

cofactor for acyl transfer

• Sinonimo/i: CoA Na₂
• Formula empirica (notazione di Hill): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• Numero CAS: 55672-92-9
• Peso molecolare: 767.53 (anhydrous free acid basis)
• Numero CE: 259-747-8
• Numero MDL: MFCD00079020
• Codice UNSPSC: 41106305
• ID PubChem: 24892587
• NACRES: NA.51

Proprietà

• Descrizione: cofactor for acyl transfer
• Saggio: ≥85% (spectrophotometric assay)
• Stato: powder
• Solubilità: H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: SYTRWOCXZXQBPW-CLVRNSBASA-M

Descrizione

Descrizione generale

Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5),[1] The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM[1]

Applicazioni

Coenzyme A is suitable for use in:

• gylcerolipid biosynthesis in porcine adipose tissue[2]
• an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor[3]
• chloramphenicol acetyltransferase (CAT) assay[4][5]
• the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion[6]

Azioni biochim/fisiol

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular metabolic dysfunction.[7] It is involved in the oxidation of pyruvate in the Kreb′s cycle. CoA is needed for metabolic events.[8] The bacterial CoA pathway is targeted for antimicrobial development.[8] It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction.[1] It acts as an essential cofactor in enzymatic acetyl transfer reactions.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)