B7777

Budesonide

≥99%

• Sinonimo/i: 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
• Formula empirica (notazione di Hill): C₂₅H₃₄O₆
• Numero CAS: 51333-22-3
• Peso molecolare: 430.53
• Numero CE: 257-139-7
• Numero MDL: MFCD00083259
• Codice UNSPSC: 12352200
• ID PubChem: 24278277
• NACRES: NA.77

Proprietà

• Saggio: ≥99%
• Stato: powder
• Ideatore: AstraZeneca
• Stringa SMILE: [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO
• InChI: 1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1; VOVIALXJUBGFJZ-KWVAZRHASA-N
• Informazioni sul gene: human ... IFNG(3458) , IL5(3567) , NR3C1(2908) ; rat ... Nr3c1(24413)

Descrizione

Azioni biochim/fisiol

Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.

Second generation glucocorticoid with low systemic absorption; anti-inflammatory agent; inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein.

Caratteristiche e vantaggi

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H317,H361d,H372,H412
• Consigli di prudenza: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
• Organi bersaglio: Adrenal gland
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)