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B150

BQ-123

≥99%, sodium salt, lyophilized powder

Sinonimo/i:

BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C31H41N6O7 Na
Numero CAS:
136553-81-6
Peso molecolare:
632.68
NACRES:
NA.32
PubChem Substance ID:
24891595
UNSPSC Code:
12352204
MDL number:
MFCD00133204
Assay:
≥99%
Form:
lyophilized powder
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Quality Segment

200

assay

≥99%

form

lyophilized powder

storage temp.

−20°C

SMILES string

[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

InChI

1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChI key

VYCMAAOURFJIHD-PJNXIOHISA-N

Gene Information

human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)

Application

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Biochem/physiol Actions

BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor. It is a cyclic pentapeptide.
Selective ETA endothelin receptor antagonist.

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Questo articolo
SML2756SML3515V0627
BQ-123 ≥99%, sodium salt, lyophilized powder

Sigma-Aldrich

B150

BQ-123

Bremelanotide acetate ≥98% (HPLC)

Sigma-Aldrich

SML2756

Bremelanotide acetate

Bulevirtide trifluoroacetate ≥98% (HPLC)

Sigma-Aldrich

SML3515

Bulevirtide trifluoroacetate

Valinomicina ≥98% (TLC), ≥90% (HPLC)

Sigma-Aldrich

V0627

Valinomicina

description

≥99%, sodium salt, lyophilized powder

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (TLC), ≥90% (HPLC)

form

lyophilized powder

form

powder

form

(Powder or Lyophilized powder or film)

form

powder

assay

≥99%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC), ≥98% (TLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

300

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

Gene Information

human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)

Gene Information

-

Gene Information

-

Gene Information

-

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

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Questions

1–4 of 4 Questions  

  1. How should Product B150, BQ-123, be dissolved?

    1 answer

    1. This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.

      Helpful?

  2. What is the solution stability for Product B150, BQ-123?

    1 answer

    1. We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned.  Cardillo, C. et al., Hypertension, 33, 753-758 (1999).  The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment.  Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. Is Product B150 the free acid form of BQ-123, or is it a salt?

    1 answer

    1. Product No. B150 is BQ123 sodium salt.

      Helpful?

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