A6664
4-Amidinophenylmethanesulfonyl fluoride hydrochloride
serine protease inhibitor
Sinonimo/i:
4-Amidinobenzylsulfonyl fluoride hydrochloride, p-APMSF
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About This Item
Formula empirica (notazione di Hill):
C8H9FN2O2S · HCl
Numero CAS:
Peso molecolare:
252.69
Beilstein:
9083148
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Saggio
≥97% (silver nitrate titration)
Stato
powder
Punto di fusione
190-191 ºC
Solubilità
H2O: 50 mM (Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.)
Temperatura di conservazione
−20°C
Stringa SMILE
Cl[H].NC(=N)c1ccc(CS(F)(=O)=O)cc1
InChI
1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
KHLLRHIUKOJXLL-UHFFFAOYSA-N
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Descrizione generale
4-Amidinophenylmethanesulfonyl fluoride hydrochloride is relatively nontoxic.[1]
Applicazioni
4-Amidinophenylmethanesulfonyl fluoride hydrochloride has been used:
- as a component of inhibitor cocktail for whole blood collection and separation of plasma[2]
- as a component of sodium dodecyl sulfate (SDS) sample buffer to prepare whole-cell extract[3]
- as a trypsin inhibitor to measure its inhibition efficiency and to determine the efficacy of the quantum dot fluorescence resonance energy transfer (FRET)-based enzymatic probes[1]
Azioni biochim/fisiol
4-Amidinophenylmethanesulfonyl fluoride hydrochloride (p-APMSF) can inhibit the trypsin-like proteinase produced by Fusarium culmorum.[4] It is also capable of blocking bovine Factor Xa, human plasmin, and the human complement proteases, C1r and C1s.
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM.
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Anja I Pekkarinen et al.
Journal of agricultural and food chemistry, 50(13), 3849-3855 (2002-06-13)
The fungal disease Fusarium head blight occurs on wheat (Triticum spp.) and barley (Hordeum vulgare L.) and is one of the worldwide problems of agriculture. It can be caused by various Fusarium species. We are characterizing the proteinases of F.
R Laura et al.
Biochemistry, 19(21), 4859-4864 (1980-10-14)
p-(Amidinophenyl)methanesulfonyl fluoride (p-APMSF) has been synthesized and shown to be a specific, irreversible inhibitor of the class of plasma serine proteases which demonstrate substrate specificity for the positively charged side chains of the amino acid lysine or arginine. In equimolar
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Analytical chemistry, 79(1), 208-214 (2006-12-30)
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