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Merck
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Documenti

58756

Sigma-Aldrich

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine

≥98.0% (HPLC)

Sinonimo/i:

1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7

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About This Item

Formula empirica (notazione di Hill):
C14H17N3O2S
Numero CAS:
84477-73-6
Peso molecolare:
291.37
Beilstein:
5445506
Numero MDL:
MFCD00132900
Codice UNSPSC:
12352202
ID PubChem:
57651659
NACRES:
NA.77

Saggio

≥98.0% (HPLC)

Forma fisica

powder

Temperatura di conservazione

2-8°C

Stringa SMILE

CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
QGSCXAWTTISKLF-UHFFFAOYSA-N

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Azioni biochim/fisiol

Less potent inhibitor of protein kinaseC than H-7

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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J Duraj et al.
Neoplasma, 44(4), 205-211 (1997-01-01)
The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45R0. Immunoprecipitation revealed two antigen specificities on
C D Balaban et al.
Brain research, 845(1), 97-101 (1999-10-26)
This study tests the hypothesis that activation of protein kinase C (PKC) is a critical step for early recovery from spontaneous nystagmus after unilateral ablation of the vestibular periphery. Halothane-NO(2)-O(2)-anesthetized Long-Evans rats received a 5-microl intracerebroventricular bolus of vehicle (distilled
B L Sailer et al.
Cytometry, 31(3), 208-216 (1998-03-27)
Fluorescence lifetime analysis was used in combination with conventional flow cytometric analysis to monitor changes in residual chromatin in apoptotic HL-60 cell populations following treatment with camptothecin, cycloheximide, genistein, H7, and gamma radiation. Data presented show that all of these
A Broberg et al.
Biochemical and biophysical research communications, 280(1), 328-333 (2001-02-13)
Integrin alpha1beta1, one of the cellular collagen receptors, can participate in the regulation of collagen accumulation by acting as a negative feedback regulator. The molecular mechanism behind this phenomenon has been unknown. We have plated cells inside three-dimensional collagen and
H Takahashi et al.
Biological & pharmaceutical bulletin, 20(4), 446-448 (1997-04-01)
Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal membrane resistance (Rm)
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