27655

Colistin sodium methanesulfonate

from Bacillus colistinus

• Sinonimo/i: Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
• Formula empirica (notazione di Hill): C₅₈H₁₁₅N₁₆Na₅O₂₈S₅
• Numero CAS: 8068-28-8
• Peso molecolare: 1759.90
• Numero CE: 232-516-9
• Numero MDL: MFCD00130824
• Codice UNSPSC: 51102829
• ID PubChem: 57648263
• NACRES: NA.85

Proprietà

• Origine biologica: Bacillus colistinus
• Forma fisica: powder or crystals
• Residuo alla calcinazione: ~20%
• Perdita: ≤5.0% loss on drying
• Colore: white to off-white
• pH: 6.5-8.5
• Spettro attività antibiotica: Gram-negative bacteria
• Modalità d’azione: cell membrane | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
• InChI: 1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1; WSDSONZFNWDYGZ-BKFDUBCBSA-I

Descrizione

Descrizione generale

Chemical structure: peptide

Applicazioni

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.

Azioni biochim/fisiol

Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect .

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Confezionamento

1g, 5g

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)