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23120

Sigma-Aldrich

α-Chloralose

≥98.0% (chloralose, AT)

Sinonimo/i:

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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About This Item

Formula empirica (notazione di Hill):
C8H11Cl3O6
Numero CAS:
15879-93-3
Peso molecolare:
309.53
Beilstein:
85418
Numero CE:
240-016-7
Numero MDL:
MFCD00005542
Codice UNSPSC:
12352201
ID PubChem:
57648022
NACRES:
NA.21

Saggio

≥98.0% (chloralose, AT)

Forma fisica

powder

Attività ottica

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

Impurezze

15% Beta-chloralose

Punto di fusione

178-184 °C

Solubilità

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

Stringa SMILE

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1
OJYGBLRPYBAHRT-IPQSZEQASA-N

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Azioni biochim/fisiol

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.

Componenti

mixture of isomers of ~85% α-chloralose; ~15% β-chloralose

Altre note

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H301,H332,H336,H410

Classi di pericolo

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
Karla Krautwald et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(2), 291-305 (2011-08-25)
To study how various anesthetics affect the relationship between stimulus frequency and generated functional magnetic resonance imaging (fMRI) signals in the rat dentate gyrus, the perforant pathway was electrically stimulated with repetitive low frequency (i.e., 0.625, 1.25, 2.5, 5, and
Congwu Du et al.
The European journal of neuroscience, 30(8), 1565-1575 (2009-10-14)
Most studies of the effect of cocaine on brain activity in laboratory animals are preformed under anesthesia, which could potentially affect the physiological responses to cocaine. Here we assessed the effects of two commonly used anesthetics [alpha-chloralose (alpha-CHLOR) and isofluorane
T Tsurugizawa et al.
Neuroscience, 165(1), 244-251 (2009-10-13)
It is important to investigate the effect of anesthesia on blood oxygenation level-dependent (BOLD) signals in an animal model. Many researchers have investigated the BOLD response to visual, sensory, and chemical stimuli in anesthetized rats. There are no reports, however
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