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13752

Sigma-Aldrich

Penicillina G

96.0-102.0%

Sinonimo/i:

Benzilpenicillina

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1 G
CHF 29.90
5 G
CHF 55.10

CHF 29.90


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Cambia visualizzazione
1 G
CHF 29.90
5 G
CHF 55.10

About This Item

Formula empirica (notazione di Hill):
C16H17N2NaO4S
Numero CAS:
Peso molecolare:
356.37
Beilstein:
3834217
Numero CE:
Numero MDL:
Codice UNSPSC:
51283424
eCl@ss:
34010400
ID PubChem:
NACRES:
NA.85

CHF 29.90


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Livello qualitativo

Saggio

96.0-102.0%

Stato

powder

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

cell wall synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
FCPVYOBCFFNJFS-LQDWTQKMSA-M

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Descrizione generale

La penicillina G è un antibiotico naturale a spettro limitato. È efficace nei confronti di Streptococcus pneumoniae, streptococchi dei gruppi A, B, C e G, streptococchi non enterococchi del gruppo D, streptococchi del gruppo viridians e stafilococchi che non producono penicillinasi.
Struttura chimica: ß-lattame

Applicazioni

La penicillina G è stata usata per studiare la proteina legante la penicillina 2[1] e il Corynebacterium diphtheriae non tossigeno isolato da casi di faringite[2].

Azioni biochim/fisiol

Modalità d′azione: La penicillina G agisce inibendo la sintesi della parete cellulare attraverso il legame con le proteine leganti la penicillina (PBP) e inibendo il legame crociato con le catene dei peptidoglicani.

Spettro antimicrobico: Il prodotto è attivo nei confronti di batteri gram positivi e gram negativi.

Confezionamento

1 G, 5 G

Avvertenza

Le soluzioni devono essere sterilizzate per filtrazione e conservate a 2-8 °C per 1 settimana o a -20 °C per periodi più lunghi. Le soluzioni sono stabili a 37 °C per 3 giorni. Il sale di sodio è solubile in H2O a 100 mg/mL.

Altre note

Tenere il contenitore ben chiuso in luogo asciutto e ben ventilato. Il prodotto contiene penicillina.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificati d'analisi (COA)

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Penicillina G 95.0 - 102.0%

Sigma-Aldrich

PENK

Penicillina G

Penicillina G United States Pharmacopeia (USP) Reference Standard

USP

1502508

Penicillina G

Penicillina G European Pharmacopoeia (EP) Reference Standard

B0700000

Penicillina G

USP

USP

1502009

Penicillin G benzathine

C von Hunolstein et al.
The Journal of antimicrobial chemotherapy, 50(1), 125-128 (2002-07-04)
Twenty-four strains of non-toxigenic Corynebacterium diphtheriae biotype gravis from the throats of patients with pharyngitis/tonsillitis were assayed for susceptibility to penicillin and erythromycin using determination of MIC, MBC and time-kill curves. There were no differences between the MICs of penicillin
Susumu Ochiai et al.
The Journal of antimicrobial chemotherapy, 60(1), 54-60 (2007-06-02)
In Neisseria gonorrhoeae, the mosaic structure of penicillin-binding protein 2 (PBP 2), composed of fragments of PBP 2 from Neisseria cinerea and Neisseria perflava, was significantly associated with decreased susceptibility to cephalosporins, particularly oral cephalosporins. The aim of this study
Paul P Drury et al.
Neuropharmacology, 83, 62-70 (2014-04-15)
Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival
Nandita Pasari et al.
Scientific reports, 9(1), 6091-6091 (2019-04-17)
Paenibacillus polymyxa A18 was isolated from termite gut and was identified as a potential cellulase and hemicellulase producer in our previous study. Considering that members belonging to genus Paenibacillus are mostly free-living in soil, we investigated here the essential genetic
Li Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 659-667 (2013-01-09)
Antifolates, in particular methotrexate (MTX), have been widely used in the treatment of primary and secondary tumors of the central nervous system (CNS). Pemetrexed (PMX) is a novel antifolate that also exhibits potent antitumor activity against CNS malignancies. Studies have

Articoli

β-lactam antibacterials inhibit transpeptidase enzymes, preventing peptidoglycan assembly in both Gram-positive and Gram-negative bacteria.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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