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X114

Sigma-Aldrich

Triton™ X-114

laboratory grade

Sinonimo/i:

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol, Polyethylene glycol tert-octylphenyl ether

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About This Item

Formula condensata:
(C2H4O)n C14H22O, n = 7 or 8
Numero CAS:
9036-19-5
Beilstein:
2315025
Numero MDL:
MFCD00128254
Codice UNSPSC:
12161900
ID PubChem:
24902129
NACRES:
NA.21
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Grado

laboratory grade

Livello qualitativo

200

Descrizione

non-ionic

PM

average mol wt 537

Composizione

t-Oct-C6H4-(OCH2CH2)xOH, x = 7-8

Indice di rifrazione

n20/D 1.488 (lit.)

CMC

0.2 mM (20-25°C)

Temp. transizione

pour point ~−9 °C
cloud point 23 °C

Densità

1.058 g/mL at 25 °C (lit.)

HLB

12.4

Stringa SMILE

CC(C)(C)CC(C)(C)c1ccc(OCCOCCOCCOCCOCCOCCOCCO)cc1

InChI

1S/C28H50O8/c1-27(2,3)24-28(4,5)25-6-8-26(9-7-25)36-23-22-35-21-20-34-19-18-33-17-16-32-15-14-31-13-12-30-11-10-29/h6-9,29H,10-24H2,1-5H3
HNLXNOZHXNSSPN-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Triton™ X-114 is a nonionic detergent. It is a good detergent for solubilizing membranes having reversible phase-separation property useful for the separation of intrinsic membrane proteins.[1] Solution of Triton™ X-114 is homogeneous at 0°C but phase separation into aqueous phase and a detergent phase occurs above 20°C.[2] Phase separation of proteins in solutions of Triton™ X-114 has been investigated.[1] This octylphenol ethoxylate is compatible with anionic, cationic, and other nonionic surfactants and chemically stable in most acidic & alkaline solutions.

Applicazioni

Triton™ X-114 has been used:
  • To remove endotoxin from solutions of protein using phase separation technique[3]
  • In the extraction and purification of DNA from endotoxin[4]
  • In the biphasic extraction of lipoproteins from bacterial cell wall[5][6]
  • As a non-ionic detergent with a low cloud point (23 °C) enabling protein solubilization with phase-partitioning of hydrophilic from amphiphilic proteins

Note legali

Triton is a trademark of The Dow Chemical Company or an affiliated company of Dow

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H318,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

483.8 °F - closed cup

Punto d’infiammabilità (°C)

251 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
MKCX0957
MKCW6472
MKCV5666
MKCW4012
0000273254

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Huanhuan Li et al.
Life sciences, 231, 116548-116548 (2019-06-11)
Multidrug resistance is a major obstacle in chemotherapy, which is mainly caused by the overexpression of ATP-binding cassette (ABC) transporters. Breast cancer resistance protein (BCRP) is one of the ABC transporters and is strongly associated with multidrug resistance. Results of
Mechanism and function of a newly identified CpG DNA motif in human primary B cells.
Hartmann G and Krieg A M
Journal of Immunology, 164(2), 944-953 (2000)
Nozomu Takahashi et al.
FEBS open bio, 7(9), 1338-1349 (2017-09-15)
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Golenbock D T, et al.
Cellular Immunology, 258(1), 29-37 (2009)
G Gabarrini et al.
Journal of dental research, 97(5), 556-562 (2018-01-05)
Porphyromonas gingivalis is one of the major oral pathogens implicated in the widespread inflammatory disorder periodontitis. Moreover, in recent years, P. gingivalis has been associated with the autoimmune disease rheumatoid arthritis. The peptidylarginine deiminase enzyme of P. gingivalis (PPAD) is
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Articoli

Glycosylphosphatidylinisotol-anchored Glycoproteins Overview

Glycosylphosphatidylinisotol- (GPI) anchored proteins have been identified throughout a broad range of eukaryotic species ranging from humans to insects, yeasts, bacteria, and fungi, suggesting that they are an ancient modification.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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