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E100

Supelco

(−)-Eseroline fumarate salt

analytical standard, for drug analysis

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About This Item

Formula empirica (notazione di Hill):
C13H18N2O · C4H4O4
Numero CAS:
70310-73-5
Peso molecolare:
334.37
Numero MDL:
MFCD00055202
Codice UNSPSC:
41116107
ID PubChem:
329798872

Grado

analytical standard, for drug analysis

Livello qualitativo

100

Stato

solid

Attività ottica

[α]23/D −107.9°, c = 0.5 in methanol(lit.)

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Colore

white

Solubilità

0.1 M HCl: soluble (Solutions should be freshly prepared.)
0.1 M NaOH: soluble (Solutions should be freshly prepared.)
H2O: soluble (Solutions should be freshly prepared.)
methanol: slightly soluble (Solutions should be freshly prepared.)

applicazioni

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

[H]\C(=C(\[H])C(O)=O)C(O)=O.[H][C@]12N(C)CC[C@@]1(C)c3cc(O)ccc3N2C

InChI

1S/C13H18N2O.C4H4O4/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13;5-3(6)1-2-4(7)8/h4-5,8,12,16H,6-7H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t12-,13+;/m1./s1
PBZRRADJWNBPNY-XDRMOJKASA-N

Informazioni sul gene

human ... ACHE(43)

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Metabolite of physostigmine (eserine) that is cytotoxic in several neuronal cell lines; it displays both anti-acetylcholinesterase and opiate agonist activities; potent analgesic.

Avvertenza

Hygroscopic, photosensitive

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
074M4617V

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Swapnalee Sarmah et al.
Scientific reports, 10(1), 3951-3951 (2020-03-05)
Ethanol exposure during prenatal development causes fetal alcohol spectrum disorder (FASD), the most frequent preventable birth defect and neurodevelopmental disability syndrome. The molecular targets of ethanol toxicity during development are poorly understood. Developmental stages surrounding gastrulation are very sensitive to
A Galli et al.
Biochemical pharmacology, 31(7), 1233-1238 (1982-04-01)
The action of eseroline--(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo l-5-ol--salicylate was tested on preparations of ChE from different sources and on the longitudinal muscle of guinea-pig ileum. While eseroline is eseroline is extremely weak-acting on horse serum BuChE (Ki = 208 +/- 42 microM), it
Ross T Fennessy et al.
Nucleic acids research, 44(15), 7189-7203 (2016-04-24)
Nucleosomes, the fundamental subunits of eukaryotic chromatin, are organized with respect to transcriptional start sites. A major challenge to the persistence of this organization is the disassembly of nucleosomes during DNA replication. Here, we use complimentary approaches to map the
S M Somani et al.
Toxicology and applied pharmacology, 106(1), 28-37 (1990-10-01)
The toxic effects of physostigmine, an anticholinesterase drug, and its metabolite eseroline were investigated in three neuronal cell culture systems, mouse neuroblastoma N1E-115, rat glioma C6, and neuroblastoma-glioma hybrid NG 108-15. Physostigmine and eseroline (0.5 nM) elicited a time-dependent leakage
Chang-Soo Han et al.
Materials (Basel, Switzerland), 12(6) (2019-03-29)
Lacosamide (LCM) is a third-generation antiepileptic drug. Selective action of the drug on voltage-gated sodium channels reduces side effects. Oral administration of LCM shows good pharmacokinetic profile. However, the bitter taste of LCM is a barrier to the development of
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