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D4285

Supelco

(±)-Dropropizine

analytical standard, for drug analysis

Sinonimo/i:

3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

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About This Item

Formula empirica (notazione di Hill):
C13H20N2O2
Numero CAS:
17692-31-8
Peso molecolare:
236.31
Numero CE:
241-683-7
Numero MDL:
MFCD00079124
Codice UNSPSC:
41116107
ID PubChem:
329798797
NACRES:
NA.24

Grado

analytical standard, for drug analysis

Livello qualitativo

200

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Formato

neat

Stringa SMILE

OCC(O)CN1CCN(CC1)c2ccccc2

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
PTVWPYVOOKLBCG-UHFFFAOYSA-N

Descrizione generale

(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.

Applicazioni

(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
018F0335

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A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
Lin Yan et al.
Archives of pharmacal research, 29(6), 514-519 (2006-07-13)
A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) in dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. The mobile phase
Li-mei Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(12), 993-996 (2005-04-09)
To develop a rapid and sensitive LC/MS/MS method for the analysis of levodropropizine in plasma and study the pharmacokinetics of levodropropizine in healthy Chinese volunteers. Levodropropizine and zolmitriptan (internal standard, IS) were extracted from plasma samples and chromatographed on a
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