61767
Lectin from Triticum vulgaris
lyophilized, ≥55% (GE), powder
Sinonimo/i:
WGA, Wheat germ agglutinin
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5 MG
CHF 119.00
CHF 119.00
Spedizione prevista il29 marzo 2025
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Cambia visualizzazione
5 MG
CHF 119.00
About This Item
CHF 119.00
Spedizione prevista il29 marzo 2025
Prodotti consigliati
Origine biologica
Triticum vulgaris
Stato
powder
Qualità
lyophilized
Concentrazione
≥55% (GE)
tecniche
agglutination assay: suitable using fresh human erythrocytes
Temperatura di conservazione
2-8°C
Categorie correlate
Descrizione generale
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.[1]
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.[2]
Applicazioni
Lectin from Triticum vulgaris has been used in bone resorption assays.[3]
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.[4]
Azioni biochim/fisiol
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.[1]
Altre note
Molecular characteristics and specificity for sugar binding[2]
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Articoli
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