52619

Hexamethyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Sinonimo/i: HMDS
• Formula condensata: (CH₃)₃SiNHSi(CH₃)₃
• Numero CAS: 999-97-3
• Peso molecolare: 161.39
• Beilstein: 635752
• Numero CE: 213-668-5
• Numero MDL: MFCD00008259
• Codice UNSPSC: 12000000
• ID PubChem: 329757861
• NACRES: NA.22

Proprietà

• Grado: for GC derivatization
• Livello qualitativo: 100
• Saggio: ≥99.0% (GC)
• Forma fisica: liquid
• Qualità: LiChropur^™
• Impiego in reazioni chimiche: reagent type: derivatization reagent; reaction type: Silylations
• tecniche: gas chromatography (GC): suitable
• Indice di rifrazione: n20/D 1.407 (lit.); n20/D 1.408
• P. eboll.: 125 °C (lit.)
• Stringa SMILE: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3; FFUAGWLWBBFQJT-UHFFFAOYSA-N

Descrizione

Descrizione generale

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.

Applicazioni

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Caratteristiche e vantaggi

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Altre note

Important silylating agent

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Note legali

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H302 + H332,H311,H412
• Consigli di prudenza: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 52.5 °F - closed cup
• Punto d’infiammabilità (°C): 11.4 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter