GHRA-88HK

Human Ghrelin (ACTIVE) RIA

• Codice UNSPSC: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Proprietà

• Grado: for protein analysis
• Livello qualitativo: 100
• Descrizione: ED₈₀ = 27 ± 7pg/mL ED₅₀=125 ± 33 pg/mL ED₂₀=652 ± 179 pg/mL ; analytes available: Ghrelin; 10-2000 pg/mL (standard curve range)
• Caratteristiche: accuracy 83–114%
• Reattività contro le specie: human
• Sensibilità: 10 pg/mL
• tecniche: radioimmunoassay: suitable
• N° accesso UniProt: Q9UBU3
• Metodo di rivelazione: radioactive

Descrizione

Descrizione generale

FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.

Applicazioni

Two-day disequilibrium assay at 4°C. Sample volume: ≤ 100 μL Plasma (collected on ice) recommended

Risultati analitici

Linearity 100–142.5%

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H226,H302 + H332,H311,H370,H373,H411
• Consigli di prudenza: P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P308 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Flam. Liq. 3 - STOT RE 2 Inhalation - STOT SE 1
• Organi bersaglio: Eyes,Central nervous system, Respiratory Tract
• Codice della classe di stoccaggio: 3 - Flammable liquids