566661
SAG
≥95% (HPLC), liquid, smoothened agonist, Calbiochem®
Sinonimo/i:
InSolution Smoothened Agonist, SAG, SAG 1.3 in Solution, SAG1.3 in Solution
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About This Item
Formula empirica (notazione di Hill):
C28H28ClN3OS · 2HCl · xH2O
Peso molecolare:
562.98 (anhydrous basis)
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
product name
Smoothened Agonist, SAG, InSolution, ≥95%, 10 mM aqueous solution
Livello qualitativo
Saggio
≥95% (HPLC)
Forma fisica
liquid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Descrizione generale
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Standard Handling (A)
Stato fisico
A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
Ricostituzione
Following initial thaw, aliquot and freeze (-20°C).
Altre note
Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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