344931-M

Furin Inhibitor II

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinonimo/i: Furin Inhibitor II, Hexa-D-arginine, H-(D)RRRRRR-NH₂
• Formula empirica (notazione di Hill): C₃₆H₇₅N₂₅O₆
• Peso molecolare: 954.14
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: water: 1 mg/mL; DMSO: soluble
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.

A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.

Azioni biochim/fisiol

Primary Target
furin

Target K_i: 106 nM against Furin

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂

Stato fisico

Supplied as a trifluoroacetate salt.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable