1.00247

Acido citrico

anhydrous fine-granular, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

• Sinonimo/i: 2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
• Formula condensata: HOC(COOH)(CH₂COOH)₂
• Numero CAS: 77-92-9
• Peso molecolare: 192.12
• Beilstein: 782061
• Numero MDL: MFCD00011669
• Codice UNSPSC: 12352106
• Numero E: E330
• Numero indice EU: 201-069-1

Proprietà

• agenzia: BP; ChP; JP; Ph. Eur.; USP
• Livello qualitativo: 500
• Conformità normativa: FCC
• Tensione di vapore: <0.1 hPa ( 20 °C)
• Nome Commerciale: EMPROVE^® ESSENTIAL
• Saggio: 99.5-100.5% substance (anhydrous) basis (alkalimetric)
• Forma fisica: coarse powder
• Potenza: 3000 mg/kg LD₅₀, oral (Rat)
• Limite di esplosione: 8 %, 65 °F
• pH: 1.7 (20 °C, 100 g/L in H₂O)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• P. eboll.: 200 °C/1013 hPa (decomposition)
• Punto di fusione: 153-159 °C (lit.)
• Solubilità: water: 1330 g/L at 20 °C
• Densità: 1.665 g/cm³ at 18 °C
• Cationi in tracce: Al: ≤0.2 ppm; As: ≤1 ppm; Hg: ≤1 ppm; Pb: ≤0.5 ppm; heavy metals (as Pb): ≤5 ppm
• applicazioni: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: OC(=O)CC(O)(CC(O)=O)C(O)=O
• InChI: 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12); KRKNYBCHXYNGOX-UHFFFAOYSA-N

Descrizione

Descrizione generale

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Applicazioni

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove^® Essential is citric acid present in its water-free, fine granulated form.

Note legali

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable