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Documenti fondamentali

999993C

Avanti

14:0 Diether PC

Avanti Research - A Croda Brand 999993C

Sinonimo/i:

1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine

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About This Item

Formula empirica (notazione di Hill):
C36H76NO6P
Numero CAS:
Peso molecolare:
649.97
Codice UNSPSC:
12352211
NACRES:
NA.25

Stato

liquid

Confezionamento

pkg of 1 × 1 mL (999993C-10mg)
pkg of 1 × 2.5 mL (999993C-25mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand 999993C

Concentrazione

10 mg/mL (999993C-10mg)
10 mg/mL (999993C-25mg)

Tipo di lipide

cardiolipins
phospholipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCCCC)COCCCCCCCCCCCCCC)=O

Descrizione generale

14:0 Diether PC (phosphocholine) is a glycerophospholipid having two tetradecyl chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It has choline as the alcohol moiety, attached to the phosphate group.

Applicazioni

14:0 Diether PC or 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine might be used:
  • in lipid bicelles to reconstitute EmrE (secondary active transport protein) to study the chain length dependence by differential scanning calorimetry and solid-state nuclear magnetic resonance (NMR)
  • to compose isotropically tumbling small bicelles, to study its size and morphology
  • to prepare bicelle samples for solid-state NMR experiments to determine if the proteins could be reconstituted into phospholipid bilayers

Confezionamento

5 mL Clear Glass Sealed Ampule (999993C-10mg)
5 mL Clear Glass Sealed Ampule (999993C-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pittogrammi

Skull and crossbonesHealth hazard

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

does not flash

Punto d’infiammabilità (°C)

does not flash


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Certificati d'analisi (COA)

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Expression and purification of the membrane protein p7 from hepatitis C virus
Cook GA, et al.
Pept. Sci., 96(1), 32-40 (2011)
Assessing interactions between a polytopic membrane protein and lipid bilayers using differential scanning calorimetry and solid-state NMR
Banigan JR, et al.
The Journal of Physical Chemistry B, 122(8), 2314-2322 (2018)
Assessing the size, stability, and utility of isotropically tumbling bicelle systems for structural biology
Wu H, et al.
Biochimica et Biophysica Acta - Biomembranes, 1798(3), 482-488 (2010)
H A Pérez et al.
Langmuir : the ACS journal of surfaces and colloids, 36(10), 2644-2653 (2020-02-20)
The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC)
Structural and functional roles of ether lipids
Dean JM and Lodhi IJ
Protein & cell, 9(2), 196-206 (2018)

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