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700116P

Avanti

7-dehydrocholesterol-d7

7-dehydrocholesterol-d7, powder

Sinonimo/i:

111110

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1 MG
CHF 418.00

CHF 418.00

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1 MG
CHF 418.00

About This Item

Formula empirica (notazione di Hill):
C27H37D7O
Numero CAS:
388622-58-0
Peso molecolare:
391.68
Numero MDL:
MFCD22570234
Codice UNSPSC:
41141804
NACRES:
NA.25

CHF 418.00

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Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 1 mg (700116P-1mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 700116P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Stringa SMILE

O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)C3=CC=C2C1)C)C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
UCTLRSWJYQTBFZ-UDEPUTHCSA-N

Descrizione generale

7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes.[1] 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3.[1] The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol.[2] 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

Applicazioni

7-dehydrocholesterol-d7 has been used:
  • as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis[3]
  • in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis[4]
  • to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis[2]

Azioni biochim/fisiol

7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. [5] Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).[2]

Confezionamento

5 mL Amber Glass Screw Cap Vial (700116P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

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Hanul Kim et al.
Frontiers in microbiology, 6, 54-54 (2015-03-12)
Concern about global warming has prompted an intense interest in developing economical methods of producing biofuels. Microalgae provide a promising platform for biofuel production, because they accumulate high levels of lipids, and do not compete with food or feed sources.
Andrzej T Slominski et al.
PloS one, 4(2), e4309-e4309 (2009-02-05)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production
Galya Staneva et al.
Langmuir : the ACS journal of surfaces and colloids, 32(6), 1591-1600 (2016-01-20)
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between
Xiao-Jing Guo et al.
Biotechnology for biofuels, 11, 192-192 (2018-07-22)
7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3. Microbial production of 7-DHC from simple carbon has been recognized as an attractive complement to the traditional
Anika V Prabhu et al.
The Journal of biological chemistry, 291(16), 8363-8373 (2016-02-19)
Cholesterol is detrimental to human health in excess but is also essential for normal embryogenesis. Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. 7-Dehydrocholesterol reductase (DHCR7) is the terminal enzyme of cholesterol
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