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Merck
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Documenti

901749

Sigma-Aldrich

(R)-5-((1H-1,2,3-Triazol-1-yl)methyl)-3-(3-fluoro-4-iodophenyl)oxazolidin-2-one

Sinonimo/i:

Aryl halide chemistry informer library compound X14

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About This Item

Formula empirica (notazione di Hill):
C12H10FIN4O2
Numero CAS:
501939-95-3
Peso molecolare:
388.14
Codice UNSPSC:
12352101
NACRES:
NA.22

Forma fisica

powder or crystals

Punto di fusione

195-200 °C (w/ decomp.)

Categorie correlate

Applicazioni

This product is Informer compound X14 of the Aryl halide chemistry informer library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the informer library, chemists can directly compare and analyze a reactions′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

Avvertenza

Not fully tested.

Altre note

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods, Chem. Sci., 2016, 7, 2604-2613

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
Buitrago Santanilla, et al.
Science, 347, 49-53 (2015)
Alexander Buitrago Santanilla et al.
Science (New York, N.Y.), 347(6217), 49-53 (2015-01-03)
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Over the past two decades, there have been major developments in transition metal-catalyzed aminations of aryl halides to form anilines, a common structure found in drug agents, natural product isolates, and fine chemicals. Many of these approaches have enabled highly
Peter S Kutchukian et al.
Chemical science, 7(4), 2604-2613 (2016-04-21)
Major new advances in synthetic chemistry methods are typically reported using simple, non-standardized reaction substrates, and reaction failures are rarely documented. This makes the evaluation and choice of a synthetic method difficult. We report a standardized complex molecule diagnostic approach

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