Hydrogen peroxide-18O2, isotopically labeled analogue of hydrogen peroxide.
Applicazioni
18O-labeled H2O2 is used to determine absolute rate and pathway of peroxide formation and decay processes in surface waters of a coastal marine site and also use to measure absolute rates of dark H2O2 production in freshwater systems. It is used to study the acetylcoenzyme A (Ac-CoA) metabolism and potential therapeutic approach for cognitive disabilities on D(16) mouse model of down syndrome.
Confezionamento
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Photochemical production is usually considered to be the main source of H2O2 in freshwater systems; here we show that significant dark production also occurs. We used isotope-labeled H2O2 as a tracer to simultaneously determine H2O2 production and decay rates in
Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus lipogenesis and protein acetylation. However, its source is unclear. Here, we report that pyruvate, the end product of glycolysis and key node in central carbon metabolism, quantitatively generates acetate
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the
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