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465119

Sigma-Aldrich

Baicalein

98%

Sinonimo/i:

5,6,7-Trihydroxyflavone

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About This Item

Formula empirica (notazione di Hill):
C15H10O5
Numero CAS:
491-67-8
Peso molecolare:
270.24
Beilstein:
272683
Numero MDL:
MFCD00017459
Codice UNSPSC:
12352100
ID PubChem:
24870246
NACRES:
NA.22

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Saggio

98%

Stato

solid

Punto di fusione

256-271 °C (lit.)

Gruppo funzionale

ketone
phenyl

Stringa SMILE

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
FXNFHKRTJBSTCS-UHFFFAOYSA-N

Informazioni sul gene

mouse ... Hexa(15211)
rat ... Alox15(81639) , Alox5(25290)

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Categorie correlate

Descrizione generale

Baicalein, a flavonoid, is a xanthine oxidase inhibitor.[1] Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.[2]

Applicazioni

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.[3]

Azioni biochim/fisiol

The flavonoid component of Nepalese and Sino-Japanese crude drugs.[4][5] Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCX1335
MKCR0734
0000195123
0000239789
0000195123

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Candidone ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00135

Candidone

Scutellarein ≥98% (HPLC)

Sigma-Aldrich

S0327

Scutellarein

Chrysin ≥96.5%

Sigma-Aldrich

C80105

Chrysin

Wogonin hydrate ≥98% (HPLC), solid

Sigma-Aldrich

W0769

Wogonin hydrate

Wei-Tien Chang et al.
The American journal of Chinese medicine, 41(2), 315-331 (2013-04-04)
Previous studies suggest baicalein, in addition to its antioxidant effects, protects against hypoxia/reoxygenation injury via its pro-oxidant properties. We hypothesize that a brief period of baicalein treatment prior to ischemia/reperfusion (I/R) may trigger preconditioning protection via a mitochondrial pro-oxidant mechanism.
Yuh-Chiang Shen et al.
European journal of pharmacology, 465(1-2), 171-181 (2003-03-26)
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied. Both baicalin and baicalein diminished fMLP- or PMA-induced reactive oxygen intermediates production in
Wujun Dong et al.
Acta pharmaceutica Sinica. B, 10(8), 1576-1585 (2020-09-24)
Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within
D E Shieh et al.
Anticancer research, 20(5A), 2861-2865 (2000-11-04)
Xanthine oxidase inhibitors are known to be therapeutically useful for the treatment of hepatitis and brain tumor. Baicalein, baicalin and wogonin, isolated from Scutellaria rivularis, have been reported to exhibit a strong activity on xanthine oxidase inhibition. In this study
Yefei Zhou et al.
Poultry science, 98(7), 2790-2799 (2019-02-20)
Baicalein, the main flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been demonstrated to exert multiple pharmacological effects, and thus could be utilized as a potential feed additive in broiler chickens. This study evaluated the effects of broiler
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Articoli

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. At what percentage of DMso baicalein and naringin will be dissolved?

    1 answer

    1. Baicalein and can be soluble in 20mg/ml DMSO. Naringin can be soluble in 10 mg/ml neat DMSO.

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