L9283

Luteolin

≥98% (TLC), powder, antioxidant

• Sinonimo/i: 3′,4′,5,7-Tetrahydroxyflavone
• Formula empirica (notazione di Hill): C₁₅H₁₀O₆
• Numero CAS: 491-70-3
• Peso molecolare: 286.24
• Beilstein: 292084
• Numero CE: 207-741-0
• Numero MDL: MFCD00017309
• Codice UNSPSC: 12352200
• ID PubChem: 24896520
• NACRES: NA.77

Proprietà

• Nome del prodotto: Luteolin, ≥98% (TLC), powder
• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Stato: powder
• Durata: 3 yr
• Colore: yellow
• Punto di fusione: ~330 °C (lit.)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccc(O)c(O)c3
• InChI: 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H; IQPNAANSBPBGFQ-UHFFFAOYSA-N
• Informazioni sul gene: human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , GSK3A(2931) ; mouse ... Hexa(15211) ; rat ... Il4(287287) , Tnf(24835)

Descrizione

Descrizione generale

Luteolin (3′,4′,5′,7′-tetrahydroxyflavone), a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery, green peppers and chamomile tea.[1] Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss,[2] aerial part of Dracocephalum kotschyi,[3] and contributes to the antioxidant potential of the plant.[2][3] Luteolin possesses antioxidant, anti-inflammatory properties,[3][4] and exerts anti-tumor potential primarily through apoptosis.[1][3] Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics.[1] Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production.[4] The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer′s disease.[5] In plants, luteolin induces nodulation protein F (nodF) gene.[6][7]

Applicazioni

Luteolin has been used:

• to induce and elucidate the apoptotic pathway in renal cell carcinoma 786-O cells[1]
• as an additive in M9 minimal medium to induce nodF gene expression[6]
• as a reference standard to qualitatively and quantitatively analyse luteolin using reverse phase-high performance liquid chromatography with diode array detector (RP-HPLC-DAD)[2]
• as a reaction supplement for β-galactosidase assay[7]
• to elucidate the anti-inflammatory efficacy of luteolin in pseudorabies virus infected RAW264.7 cell line by measuring the anti-inflammatory mediators production and also cell viability and cytotoxicity assay[4]

Azioni biochim/fisiol

Hydroxylated flavone derivative, a strong antioxidant and radical scavenger. Suggested to play a role in prevention of cancer, possibly via the inhibition of fatty acid synthase activity.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves