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386529

Sigma-Aldrich

Chlorotrimethylsilane

purified by redistillation, ≥99%

Sinonimo/i:

TMSCl, TMCS, Trimethylchlorosilane, Trimethylsilyl chloride

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About This Item

Formula condensata:
(CH3)3SiCl
Numero CAS:
75-77-4
Peso molecolare:
108.64
Beilstein:
1209232
Numero CE:
200-900-5
Numero MDL:
MFCD00000502
Codice UNSPSC:
12352302
ID PubChem:
24864097
NACRES:
NA.22

Densità del vapore

3.7 (vs air)

Livello qualitativo

200

Tensione di vapore

100 mmHg ( 25 °C)

Saggio

≥99%

Forma fisica

liquid

Temp. autoaccensione

752 °F

Purificato mediante

glass distillation
redistillation

Limite di esplosione

6.4 %

Impurezze

<0.1% dichlorodimethylsilane

Indice di rifrazione

n20/D 1.387 (lit.)

P. eboll.

57 °C (lit.)

Punto di fusione

−40 °C (lit.)

Densità

0.856 g/mL at 25 °C (lit.)

Stringa SMILE

C[Si](C)(C)Cl

InChI

1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
IJOOHPMOJXWVHK-UHFFFAOYSA-N

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Descrizione generale

Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.

Applicazioni

Chlorotrimethylsilane (TMSCl) can be used as:       
  • A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.      
  • A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.        
  • A trapping agent for the anions generated during acyloin condensation reaction.       
  • A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
  •  A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.        
  • A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.       
  • A reagent in Fischer glycosidation.       
  • A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et3SiH.
  • A reagent to synthesize sodium trimethylsilanethiolate (Me3SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me3SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.

Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H331,H312,H314

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

Rischi supp

EUH014

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

-18.4 °F - closed cup

Punto d’infiammabilità (°C)

-28 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles

Certificati d'analisi (COA)

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