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11970

Sigma-Aldrich

1,3-Diphenyl-2-propenone

≥98.0% (GC)

Sinonimo/i:

Benzalacetophenone, Chalcone

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About This Item

Formula condensata:
C6H5CH=CHCOC6H5
Numero CAS:
94-41-7
Peso molecolare:
208.26
Beilstein:
1210466
Numero CE:
202-330-2
Numero MDL:
MFCD00003082
Codice UNSPSC:
12352100
ID PubChem:
57646947
NACRES:
NA.22

Saggio

≥98.0% (GC)

Solubilità

dioxane: soluble 1 g/10 mL, clear, colorless

Stringa SMILE

O=C(\C=C\c1ccccc1)c2ccccc2

InChI

1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
DQFBYFPFKXHELB-VAWYXSNFSA-N

Informazioni sul gene

rat ... Ar(24208)

Applicazioni

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Azioni biochim/fisiol

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

688827

trans-1-Phenyl-2-buten-1-one

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Sigma-Aldrich

669237

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Sigma-Aldrich

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Y L Hsu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 44(5), 704-713 (2005-11-26)
Chalcones are discussed to represent cancer preventive food components in a human diet that is rich in fruits and vegetables. In this study, we examined chalcone (1,3-diphenyl-2-propenone) for its effect on proliferation in human breast cancer cell lines, MCF-7 and
Jie Li et al.
Neuroscience letters, 535, 51-56 (2013-01-22)
Inflammation is a pivotal pathological progress in the development of ischemic stroke. Modulating inflammatory cytokines released by microglia is thought to be a potential strategy for the treatment of ischemic stroke. Hydroxy-safflor yellow A (HSYA), a chemical component of the
Jeanne A Geyer et al.
Bioorganic & medicinal chemistry letters, 19(7), 1982-1985 (2009-03-03)
The cyclin dependent protein kinases, Pfmrk and PfPK5, most likely play an essential role in cell cycle control and differentiation in Plasmodium falciparum and are thus an attractive target for antimalarial drug development. Various 1,3-diaryl-2-propenones (chalcone derivatives) which selectivity inhibit
Ahmed Kamal et al.
Expert opinion on drug discovery, 8(3), 289-304 (2013-01-16)
Imidazothiazole derivatives have long been therapeutically used for the treatment of various diseases. In recent years, the imidazothiazole and chalcone moieties have emerged as important pharmacophores in the development of antitumor agents. Imidazothiazole-chalcone conjugates can be accessed by covalently binding
Liang-Zhong Lv et al.
International journal of nanomedicine, 7, 4099-4107 (2012-08-14)
Hydroxysafflor yellow A (HSYA), the main active ingredient of the safflower plant (Carthamus tinctorius L.), is a hydrophilic drug with low oral bioavailability. Water-in-oil-in-water (w/o/w) double emulsions may enhance the oral absorption of HSYA. In this study, we prepared a
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