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114715

Sigma-Aldrich

Phenylhydrazine hydrochloride

≥99%

Sinonimo/i:

Phenylhydrazinium chloride

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5 G
CHF 10.30
100 G
CHF 54.40
500 G
CHF 306.00

CHF 10.30

Spedizione prevista il18 marzo 2025

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Cambia visualizzazione
5 G
CHF 10.30
100 G
CHF 54.40
500 G
CHF 306.00

About This Item

Formula condensata:
C6H5NHNH2 · HCl
Numero CAS:
59-88-1
Peso molecolare:
144.60
Beilstein:
3594958
Numero CE:
200-444-7
Numero MDL:
MFCD00012924
Codice UNSPSC:
12352100
ID PubChem:
24847191
NACRES:
NA.22

CHF 10.30

Spedizione prevista il18 marzo 2025

Richiedi un ordine bulk

Livello qualitativo

200

Saggio

≥99%

Stato

solid

Punto di fusione

250-254 °C (dec.) (lit.)

Solubilità

H2O: soluble 50 mg/mL

Gruppo funzionale

hydrazine

Stringa SMILE

Cl[H].NNc1ccccc1

InChI

1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H
JOVOSQBPPZZESK-UHFFFAOYSA-N

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Applicazioni

Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice[1].

Azioni biochim/fisiol

Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice[2]. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals[3].

Nota sulla preparazione

50 gm of Phenylhydrazine hydrochloride dissolves in 1 mL of water to yield a clear, very faint yellow solution.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
BCCJ6929
BCCJ6913
BCCJ6912
BCCD8581
BCCD8580

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Sigma-Aldrich

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Potassium ferricyanide(III)

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Sigma-Aldrich

F14203

4-Fluorophenylhydrazine hydrochloride

Phenylhydrazine as inhibitor of horseradish peroxidase for use in immunoperoxidase procedures.
W Straus
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 20(11), 949-951 (1972-11-01)
Clinton Stewart et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 22(1), 612-629 (2019-12-10)
Cyclophosphamide is widely used to treat children with medulloblastoma; however, little is known about its brain penetration. We performed cerebral microdialysis to characterize the brain penetration of cyclophosphamide (130 mg/kg, IP) and its metabolites [4-hydroxy-cyclophosphamide (4OH-CTX) and carboxyethylphosphoramide mustard (CEPM)]
Emanuela Tolosano et al.
Blood, 100(12), 4201-4208 (2002-10-24)
Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and hemopexin are thought to play a crucial role. Haptoglobin and
Y Yamamura et al.
Molecular and cellular biology, 18(3), 1172-1180 (1998-03-06)
Abnormal erythropoietin (EPO)-independent cell growth is induced after infection of erythroid progenitor cells with a polycythemic strain of Friend virus (FVp). Binding of its Env-related glycoprotein (gp55) to the EPO receptor (EPOR) mimics the activation of the EPOR with EPO.
Jason S Nagati et al.
PloS one, 14(11), e0225105-e0225105 (2019-11-15)
The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcription factors include HIF-2, which is activated under conditions of oxygen
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can we store aliquots of PHZ (dissolved in PBS) in -20? How long does it remain stable? Thanks!

    1 answer

    1. This product has not been evaluated for stability in solution. Phenylhydrazine HCl solutions may decompose when exposed to light and air. There are commercially available solutions in water that are packaged in amber glass and have an approximate shelf life of 1 year at room temperature, according to manufacturers. Note that this information has not been validated.

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  4. Como puedo saber la fecha de caducidad si no aparece en el CoA?

    1 answer

    1. This product does not contain an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

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