UBE3A
ubiquitin protein ligase E3A
Sinonimi:
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
Specie:
Human UBE3A (7337), Mouse Ube3a (22215), Rat Ube3a (361585), naked mole-rat Ube3a (101709173), Domestic Rabbit UBE3A (100342825), sheep UBE3A (101114391), domestic guinea pig Ube3a (100730511), dog UBE3A (479010), domestic cat UBE3A (101089941), cow UBE3A (533136) ...Più
ID UniProtKB:
ID gene:
- Human(7337) Summary: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(22215) ubiquitin protein ligase E3A
- Rat(361585) ubiquitin protein ligase E3A
- naked mole-rat(101709173) ubiquitin protein ligase E3A
- Domestic Rabbit(100342825) ubiquitin protein ligase E3A
- sheep(101114391) ubiquitin protein ligase E3A
- domestic guinea pig(100730511) ubiquitin protein ligase E3A
- dog(479010) ubiquitin protein ligase E3A
- domestic cat(101089941) ubiquitin protein ligase E3A
- cow(533136) ubiquitin protein ligase E3A
- Horse(100050725) ubiquitin protein ligase E3A
- Zebrafish(792398) ubiquitin protein ligase E3A
- fruit fly(39266) Ubiquitin protein ligase E3A
- chicken(418686) ubiquitin protein ligase E3A
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Monoclonal Anti-UBE3A antibody produced in mouse, clone 3E5, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot
western blot
Anti-UBE3A antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-UBE3A antibody produced in mouse, clone 2F6, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-UBE3A Antibody, clone 10H7.1, clone 10H7.1, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-E6AP Antibody, serum, from rabbit,
Reattività con
human, mouse, rat
Applicazione
immunoprecipitation (IP)
western blot
western blot
Proteins
N° Catalogo
Descrizione
Specie
UBE3A active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥72% (SDS-PAGE),
Specie
human
esiRNA
N° Catalogo
Descrizione
Specie